Thu, 26 Sep 2019, 16:00 CEST (Berlin)

Dr. Torsten Hoffmann, Taros Chemicals GmbH & Co. KG, Dortmund, Germany

Small molecules, peptides and oligoribonucleotides — 3 medchem tales

Three personal drug discovery case studies will be presented from the medicinal chemistry perspective:

  1. the design and discovery of the small molecule Netupitant, an FDA approved anti-emetic medicine since 2014,
  2. the design and discovery of the peptide therapeutic Dasiglucagon for the treatment of severe hypoglycemia in diabetic patients, currently in late stage clinical phase 3 trials, and
  3. the design and preclinical characterization of a therapeutic GalNAc-siRNA conjugate for the treatment of rare blood disorders, for which the CTA has been recently approved.
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