After the re-docking of generated compounds, the final binding mode assessment & filtering step, our Chemical Space Docking service delivers a set of molecules that are likely to bind to the target of interest. Since chemical rules have been applied to create the Chemical Space (e.g., robust chemical reactions
or in-house knowledge), hit candidates have a very high likelihood of synthetic accessibility.
Several pharmaceutical companies have already utilized the concept of combinatorial reaction chemistry to create their own, proprietary Chemical Spaces
. Renowned chemical compound makers have inhaled the power and possibilities behind this approach and responded with their own Chemical Spaces
: Users can search for commercially available, "make-on-demand" compounds. The application of robust in-house chemical reactions is reflected in a high synthetic success rate and with delivery rates of a few weeks.