After the redocking of generated compounds, the final binding mode assessment & filtering, our Chemical Space Docking delivers a set of molecules that are likely to bind to the target of interest. Since chemical rules have been applied to create the Chemical Space (e.g.
robust chemical reactions or in-house knowledge), hit candidates have a high likelihood of synthetic accessibility.
Several pharmaceutical companies already utilize the concept of combinatorial reaction chemistry
to create their own, proprietary Chemical Spaces. Renown chemical compound makers have inhaled the power and possibilities behind this approach and responded with
their own Chemical Spaces: Users can search for commercially available, "make-on-demand" compounds. The application of robust in-house chemical reactions is reflected in a high synthetic success rate and delivery rates of few weeks.