Crossing the 100 Billion Mark
REAL Space has entered the 100+ billion era. The October update brings Enamine’s Chemical Space to 113,699,103,092 virtual product molecules, opening up an even larger collection of make-on-demand chemistry for your drug discovery projects. Built from 211,806 building blocks and 161 chemical reactions, implemented as 910 technical reactions, this release marks another milestone in the long-standing collaboration between Enamine and BioSolveIT.
REAL Space October Update at a Glance
- 113,699,103,092 virtual product molecules
- 211,806 building blocks
- 161 chemical reactions
More Chemistry. Greater Possibilities.
- ~20% more virtual product molecules
Over 19 billion additional compounds, taking REAL Space beyond 100 billion - 10,555 additional building blocks
A ~5% larger pool of synthetic starting points
Enamine: Our Pioneering Partner
Enamine is now recognized as BioSolveIT’s Pioneering Partner, celebrating a collaboration that has helped shape the way researchers explore Chemical Space since 2018. Enamine contributes its synthetic expertise, building blocks, and validated reaction protocols; BioSolveIT turns this chemistry into a searchable resource through its Chemical Space technology.
Together, we connect compound exploration with practical access to molecules for experimental testing. Crossing the 100 billion mark is a shared achievement, and we are proud to continue this journey with Enamine.
From Millions to More Than 100 Billion
The journey began in February 2018 with the joint launch of REAL Space and REAL Space Navigator, the predecessor of today’s infiniSee. Its first release offered more than 600 million virtual compounds, combining orderable chemistry with efficient searching on modest hardware.
Regular updates brought REAL Space to approximately 11 billion compounds in 2019, 70 billion in 2024, and 95 billion in April 2026. This release takes it beyond the 1011 mark. As BioSolveIT’s longest-running Chemical Space collaboration, REAL Space continues to grow with the needs of the scientific community.
Discover the story behind the collection in our REAL Space Spotlight.
Explore 113 Billion Possibilities
Search the expanded REAL Space with infiniSee through three complementary modes: Scaffold Hopper for pharmacophore-guided similarity, Analog Hunter for fingerprint-based analog searches, and Motif Matcher for substructure and maximum common substructure searches. The corresponding command-line tools (FTrees, SpaceLight, and SpaceMACS) support integration into your own workflows.
For structure-based discovery, explore REAL Space within your target’s binding site using Chemical Space Docking® in SeeSAR. Screen for candidates with favorable binding-site interactions on standard hardware, with searches running offline.
From REAL Space to Real Compounds
REAL Space connects virtual exploration with Enamine’s make-on-demand synthesis. To request a synthesis quotation, contact libraries@enamine.net with your selected structures, compound IDs, and required quantities.
More than 100 billion possibilities. One pioneering partnership.
Explore the updated REAL Space and expect actives!