infiniSee xREAL infiniSee xREAL
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infiniSee xREAL changelog

infiniSee xREAL

The version of infiniSee dedicated to exclusively screen Enamine's trillion-sized xREAL Space: infiniSee xREAL.
Users get to experience the whole engine of infiniSee, while operating in the most valuable source for synthetically accessible and commercially available compounds.

For the overview of software-related updates, please visit the general infiniSee changelog.
infiniSee changelog
[2025-07-30]
Just like infiniSee Arke, infiniSee xREAL also benefits from the new database format for Chemical Spaces. As a result, the xREAL Space can now be searched faster than ever before.

Important notes:
  • The new database format is the new default format for infiniSee xREAL.
  • The new file format of xREAL Space is not backward compatible. When using older versions, only the old space format can be used.
  • Updates for xREAL Space will only be released in the new database format.
  • Therefore, we recommend all users to update to the latest version to ensure compatibility with the up-to-date versions of xREAL Space in the future.
  • Please note that projects created with older versions are no longer compatible with infiniSee xREAL 7.0.

Key Features
  • xREAL Space Update: The new version of the xREAL Space has doubled in size! For the first time, the number rises to a staggering 4.4 trillion tangible compounds.
  • xREAL Space Loading: The xREAL Space is now decoupled from infiniSee xREAL as a separate file and no longer included within the downloaded executable.

    Users must download the xREAL Chemical Space file separately after installation directly within the software’s interface.
  • RAM Warning Dialog Updates
    • Warning dialogs for insufficient RAM have been removed from Analog Hunter and Motif Matcher Modes.
    • In Scaffold Hopper Mode, RAM warnings will now appear only if the system has less than 16 GB of memory.
  • Feature Consistency with infiniSee: All features and improvements listed for infiniSee 7.0 'Arke' also apply to infiniSee xREAL.
    Please see the full infiniSee changelog for more details.
[2024-09-01]
The next level of screening synthetically accessible and commercially available compounds is here!
infiniSee xREAL is the only software able to operate in this trillion-sized version of Enamine's Chemical Space. Browse through the most reliable source for drug-like compounds on standard hardware without the need of large computational resources.
  • First version of xREAL: We are extremely excited to release the trillion-sized version of Enamine's REAL Space: xREAL.
    • The Chemical Space contains 2,415,473,746,619 molecules. That's 2×1012 entries: 2.4 trillion potential drug candidates!
    • 3126 chemical reactions were meticulously coded to ensure high synthesizability.
    • In its first release, xREAL contains 50-times more compounds than the general REAL Space.
  • Exclusive navigation in xREAL: infiniSee xREAL is dedicated to screen the Enamine Chemical Space.
    Users can load a molecule of interest into one of the three available search modes Scaffold Hopper, Analog Hunter or Motif Matcher to mine the trillion-sized compound collection.