The ability to produce enough food, feed, fibre and fuel for a growing population is the challenge of modern agriculture. Crop protection agrochemicals such as herbicides are an important component of current strategies to optimise crop yield. However, weed resistance in the field is a growing problem and means that active ingredients with a novel mechanism of action are at a premium. targenomix uses a systems biology approach to analyze diverse kinds of data and thereby elucidate the target of novel herbicidal compounds emerging from phenotypic screens. Core expertise in transcriptomics, metabolomics, proteomics and several flavors of phenotyping has recently been supplemented with a computational chemistry workflow. In this webinar examples will be presented of how both ligand-ligand (chemical similarity analysis) and ligand-protein (ligand-protein docking) in silico modeling approaches can contribute to hypothesis generation and validation in the target elucidation effort.