Project

The respiratory tract pathogen Streptococcus pneumoniae is a primary global cause of morbidity and mortality. Pili enhance initial adhesion as well as the capacity of pneumococci to cause pneumonia and bacteremia. Pneumococci are also responsible for serious illnesses in young children, old and HIV-infected individuals. MDR S.pneumoniae strains require rapid development of novel preventive and therapeutically sound approaches. Almost all bacterial adhesins are organized as thin thread-like elongated organelles called fimbriae or pili that perform many important bacterial processes like conjugation, adherence, twitching motility, biofilm formation. In the assembly of pilus systems of Gram-positive pathogens, heterotrimeric or -dimeric pili are covalently assembled by the trans-peptidase enzyme Sortase C (SrtC), a potent drug target. In this study we will design the inhibitors against SrtC enzyme of S.pneumonia to curb down this deadly pathogen.