Here is one of the winners of fall 2016 challenge's first three months:
In pursuit of developing potential vaccines and drugs against Flaviviridae viruses, promising targets have to be identified. Activation of non-structural proteins NS1, NS2A, NS3 and NS5 inside of mosquito-borne viruses is necessary for virial replication. At the same time, structural envelop protein is involved in entry of viral particles into the cell. Hence, inhibition of these proteins could neutralize the virus. Therefore, 10 proteins were selected as a targets: structural envelope, non-structural hydrolase and transferase for Yellow fever virus, non-structural hydrolase and methyltransferase for West Nile virus and non-structural methyltransferase, helicase, protease RNA-dependent polymerase and structural envelope for Zika virus. Top 100 compounds for each protein were identified. As genome and biochemistry of Yellow fever, West Nile and Zika viruses is similar, the main challenge was to identify lead compounds which could simultaneously inhibit all three viruses.
The following project won the 'winter 2015' scientific challenge:
For more information please visit the hall of fame.
BioSolveIT is inviting academic teams, non-profit organizations and individuals to participate in an exciting Scientific Challenge: if you are working on a drug discovery problem, take advantage of BioSolveIT's wide array of software tools to meet your goals. How to participate? Just send us a proposal for the project you'd like to advance using BioSolveIT software. We will review every proposal very carefully and award the most attractive ones. A new contest starts every three months.
In a first phase, the most promising proposals will receive free BioSolveIT licenses for 3 months to conduct the desired research. For phase II, the most interesting results are granted a free license extension by 9 months and we will sponsor the presentation of the overall best achievement with a travel grant of 1000€. For more details please read the terms of challenge.