Covalent ligands bear a functional group or motif in their molecular structure, the so-called ‘warhead’, which interacts with an nucleophile side chain (e.g. cysteine, serine, lysine, threonine) forming a bond between target and ligand. They are proposed to offer multiple advantages, including high-selectivity, low-toxicity, and modifiable in vivo half-time. Furthermore, covalent ligands are perfect candidates for high-quality complexes for crystallographic structure determination as they greatly contribute to stabilization of certain conformations.
In this webinar you will learn how to perform covalent docking with SeeSAR with insights on the translation of covalent warheads and the opportunities to profit from covalent compound suppliers.
Participants can request a certificate of attendance.
