Significant changes and improvements in SeeSAR demand another major release and version 8 well deserves to be a major update. The biggest change is that we now provide full protein visualization support. While the focus of the tool is for the most part still on the defined binding site, you can now...: see the whole protein in all its glory! As always, a major update means that HYDE scores must be re-calculated to stay in line with the changes made in the underlying structures. We certainly believe that these enhancements are well worth it:
Ease of use once again forms the focus of this new SeeSAR version 7.3. We found that the growing amount of features (editing, ReCore, docking, growing, ...) — and buttons that go with them — have impacted the clear and intuitive use a little. So we have focused on fixing this and are proud to present this update with loads of usability enhancements.
Get fresh inspiration from this huge update of SeeSAR! We realized, on the one hand, that the functionality of the editor was growing and growing, making it more and more complicated to use. On the other hand, access to the full functionality of ReCore demands a different kind of user interface. So we "took the bull by the horns" and, akin to the editor, created the new Inspirator which you can use to do:
This new version of SeeSAR is full of usability enhancements plus a new, bulk docking feature.
A lot has changed in this new version of SeeSAR, justifying again a major update release. Our focus this time lay on the editor — essentially this has now evolved to become a full-blown "Designer"! Read on below to find out all the details. Among other things, an update to the torsion distribution database as well as an improved intra-molecular clash test can lead to changes in the affinity estimations using HYDE, which is why any existing affinity estimations will be re-set if you read in a project file from an older SeeSAR version.
The all new SeeSAR 6 provides you with a completely redesigned and now fully customizable GUI. You can choose between different bright and dark themes and GUI layouts so that you can optimally adapt SeeSAR for different use cases.