Our motto for SeeSAR is "fast, visual, easy", and this is exactly why people love working with our 3D modeling platform. With version 10, we are proud to present you a major update! The most visible and striking difference is certainly the brand new design. SeeSAR has matured over the years and many additional functionalities have been added to address your day-to-day 3D modeling needs. So to keep it intuitive, we have redesigned all modes, menus, and buttons to preserve its easy-to-use character. Besides the redesign, we also present these important new features that deserve special attention:
- Protein Editor mode
Using features similar to those found in the Editor mode for small molecules, you may change the side-chain of any residue in this mode. Furthermore, you can eliminate unwanted water molecules, ions, ligands, terminal residues, or even entire chains. Protein editing is a really powerful option to overcome any deficiencies there may be in your PDB. For example, you may want to detect the interface of a PPI, or work with a wild type missing a specific mutation, or simply remove a covalent binder.
- Clipping of surfaces
Surfaces are essential to get a good sense of the shape and depth of a binding site. However, once you visualize the surface, it inevitably occludes your view. So, we are happy to introduce user-friendly clipping planes for your binding site surface. Through intuitive controls and by initializing the clipping plane optimally through the scene, SeeSAR now offers you an easy-to-use clipping experience, so that you can better visualize your ligand inside the pocket.
- Other important updates are (A) You may now use your own growing-library in the Inspirator mode. (B) Define your own SMARTS in pharmacophore constraints in order to focus more precisely on what you want or need. Finally (C) Copying molecules between modes just became much faster and is now accompanied by a progress bar.
As you can imagine, a major change like this (editing of the protein) required an update of SeeSAR's internal storage. So, unfortunately, old project files cannot be loaded with this new version. We recommend you save your molecules from old projects to file and re-read them with this SeeSAR 10.