AMBrosia Just Got Bigger: 126 Billion Compound Update Now Available

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AMBrosia Just Got Bigger: 126 Billion Compound Update Now Available

June 11, 2025 13:21 CEST

We are thrilled to announce a major update to the AMBrosia Chemical Space in collaboration with Ambinter!

The state-of-the-art source for diverse drug-like scaffolds now boasts an incredible 126 billion of synthetically accessible compounds for drug discovery projects.

What does the update feature?

  • Expanded to an astounding 125,924,571,692 compounds (1.26 × 1011, +14% compounds in total).
  • Built from carefully selected, real-world building blocks and proven reaction schemes:
    • 10 synthetic reactions added.
    • 24% increase in used building blocks.

How AMBrosia boosts your drug discovery campaigns

  • AMBrosia supplements your projects with broader chemical diversity that can be ordered directly to your table.
  • Cherry-picked building blocks and reactions deliver tailored scaffolds for faster and more efficient hit identification and lead optimization.
  • Results retrieved from AMBrosia have high synthetic feasibility. Any molecule you find can be put in physical samples within few weeks to accelerate your research workflows.

How to browse AMBrosia

  • 3D Structure-basedLatest: AMBrosia can be searched with Chemical Space Docking™ to mine for most promising candidates that form high-quality interactions in your binding site.
  • Screen for relevant chemistry using the Chemical Space navigation platform infiniSee.
  • … or use the the command-line versions of the Chemical Space exploration tools.

Explore the updated AMBrosia Space today and unlock the next breakthrough in your drug discovery journey!

Download AMBrosia following this link.