ReCore: example 2: TRH (Thyrotropin Releasing Hormone)

How does ReCore deal with 3 cutting points ("exit vectors")?

A typical ReCore query was taken from a TRH CSD crystal (TRHTRT) and torsionally modified to satisfy Olson's [1] idea (cp. below). To obtain more rigid results, a "pharmacophore" priority was introduced: A ring atom has to lie within the sphere depicted in red.
       
Based on the query (please note the green arrows), ReCore generates several interesting and nicely aligning cyclic structures; here are the ReCore results (colored) with the query in grey:
   
  Rank: 12 5 6 7
  CSD: HUWHEM KIFZAA SUMVEB TCHXET
  Note: saturated ring aromatic ring rings are good a tri-subst'd 6-ring
And, actually, the tri-substituted 6-ring was the basis for a TRH peptide mimetic by Olson [1] (in orange):
         
[1]Olson et al., . J. Med. Chem. 1995, 38, 2866-2879.

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