Due to the fuzziness of the Feature Trees descriptor different scaffolds may be detected at high similarity values.
Compared to industry standards (Daylight Fingerprints set to 100% as the reference), FTrees detects 17.7% more hits as a broad average across multiple activity classes.
Public (or your own) reactions and building blocks are fed into the computer creating a space to be searched within just minutes. Searching with a query will deliver interesting scaffold hops alongside with the receipe how to synthesize them. Read more on the FTrees-FS page.